abstract：OBJECTIVE:To study the histopathological changes of relevant internal organs of Macaca mulatta infected with Plasmodium knowlesi (P. knowlesi). METHODS:Histopathological examination of 3 monkeys who died of P. knowlesi infection, 2 P. knowlesi infected monkeys who died of treatment failure with artesunate suppository ...

journal_title：Chinese medical journal

authors： Chen L,Li G,Lu Y,Luo Z

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:To choose one optimal extrinsic positive end-expiratory pressure (PEEPe) for ventilated patients with chronic obstructive pulmonary disease (COPD) and to compare two methods for choosing the optimal level of PEEPe. METHODS:Ten ventilated patients with COPD were included in the study. First, static intrinsic ...

journal_title：Chinese medical journal

authors： Kong W,Wang C,Yang Y,Huang K,Jiang C

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:To investigate the regulation effect of protein kinase ERK on the activation of transcription factor STAT3 in response to IL-6 in the Sko-007 human myeloma cell line. METHODS:Electrophoretic mobility shift assay (EMSA) and immunoprecipitation (IP) were used to show the activation of STAT3 and ERK in Sko-007 ...

journal_title：Chinese medical journal

authors： Song L,Shen B,Li Y

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:To discuss the diagnosis and surgical treatment of temporal lobe epilepsy. METHODS:From 1996 to 1998, 36 patients presenting with medically intractable temporal lobe epilepsy were identified by EEG and MR, including volumetric MR, for hippocampal formation. Among them, 16 patients underwent anterior temporal...

journal_title：Chinese medical journal

authors： Gao X,Jiang C,Shi Y

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between the expression and regulation of osteopontin (OPN) and urolithiasis. METHODS:Normal and stone model rats were treated with 1,25-dihydroxyvitamin D3(D3), vitamin K, testosterone or estradiol for 7 days, and the expression of osteopontin and its mRNA were detected with i...

journal_title：Chinese medical journal

authors： Chang L,Feng T,Li J,Dou C,Wei J,Guo Y

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:To investigate changes in intestinal microflora in patients with chronic severe hepatitis (CSH), and their role in this life-threatening disease. METHODS:We classified nineteen patients with chronic severe hepatitis as the CSH group, thirty patients with chronic hepatitis (CH) as the CH group and thirty-one ...

journal_title：Chinese medical journal

authors： Li L,Wu Z,Ma W,Yu Y,Chen Y

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:To analyse the relationship between age and treatment with captopril after acute myocardial infarction (AMI). METHODS:In a randomized trial, 822 patients with a first AMI received conventional medical treatment, including intravenous thrombolytic therapy and oral aspirin or metoprolol, and then were randomly...

journal_title：Chinese medical journal

authors： Cai X,Shen W,Gong L

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:To determine the role of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS), and evaluate the progress from SIRS to MODS and the therapeutic strategies for acute necrotizing pancreatitis (ANP). METHODS:Rat ANP models were made by retrograde injection of 3.5% sodium ...

journal_title：Chinese medical journal

authors： Zhang Q,Ni Q,Cai D,Zhang Y,Zhang N,Hou L

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:To study the cellular mechanism of the effect of Ang II on ICa,L in single guinea-pig ventricular cells by using losartan and 1-(5-lsoquinolinylsulfonyl)-2-Methyl-Piperazine (H-7) as the Ang II type 1 receptor (AT1) inhibitor and protein kinase C inhibitor, respectively. METHODS:Patch clamp techniques were u...

journal_title：Chinese medical journal

authors： Yang X,Hui J,Jiang W

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of U14 vaccine transfected with the B7 gene in inducing antitumor immune response to murine cervical carcinoma in Chinese 615-strain mice. METHODS:A recombinant retroviral plasmid vector expressing mouse B7-1 gene (pLNSX-mB7) was transfected into 615-strain mouse cervical carcinoma ...

journal_title：Chinese medical journal

authors： Tao G,Hu J,Zou H,Lin Q,Liu F,Wu Y,Sun Q

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To investigate the distribution and clonality of the T-cell receptor (TCR) V beta repertoire in chronic graft versus host disease (cGVHD). METHODS:The complementarity determining region 3 (CDR3) of the TCR beta gene with 24 variable regions was amplified in peripheral blood mononuclear cells drawn from one c...

journal_title：Chinese medical journal

authors： Li Y,Du X,Xu M,Zhang T,Yang L,Chen S

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:To identify novel tumor suppressor genes at chromosome 3p24-26 in human nasopharyngeal carcinoma (NPC). METHODS:Twenty epithelial-derived expressed sequence tags (EST) were selected from chromosome 3p24-26. RT-PCR and Northern blot were used to detect the expression of the ESTs in NPC cell line, HNE-1, and p...

journal_title：Chinese medical journal

authors： Xie Y,Bin L,Yang J,Li Z,Yu Y,Zhang X,Cao L,Li G

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:To provide epidemiological data for revising the diagnostic criteria of neonatal hyperbilirubinemia in China. METHODS:A survey was performed among full-term infants in multiple centers throughout the country. From less than 24 hours after birth, the infants' bilirubin levels were measured every day until the...

journal_title：Chinese medical journal

authors： Ding G,Zhang S,Yao D,Na Q,Wang H,Li L,Yang L,Huang W,Wang Y,Xu J

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To analyze the effect and mechanism of hyperbaric oxygen (HBO) treatment for severe brain injury (SBI). METHODS:Fifty-five patients were divided into a treatment group of 35 patients and a control group of 20 patients. We observed the alterations of clinical, brain electric earth map (BEAM), endothelin (ET) ...

journal_title：Chinese medical journal

authors： Ren H,Wang W,Ge Z,Zhang J

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To observe the immediate angiographic and intravascular ultrasound (IVUS) results and their effects on one month clinical outcomes in forty-one patients who submitted to coronary stent deployment with IVUS guidance. METHODS:All patients were allocated to coronary stent implantation with high inflation pressu...

journal_title：Chinese medical journal

authors： Zhang D,Cai X,Shen W,Schiele F,Bassand JP

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:To study the relationship between cartilage end-plate calcification and intervertebral disc degeneration. METHODS:An experimental model of cervical disc degeneration in rabbits was established by resection of the cervical supraspinous and interspinous ligaments and detachment of the posterior paravertebral m...

journal_title：Chinese medical journal

authors： Peng B,Hou S,Shi Q,Jia L

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:To clarify the role of sexual related Y (SRY) gene detection in the diagnosis of gonadal dysgenesis. METHODS:Sixteen cases of gonadal dysgenesis were included in this study: 5 with androgen insensitivity syndrome, 1 with 17-alpha-hydroxylase deficiency, 4 with true hermaphrodite, 2 with 45, X/46, XY gonadal ...

journal_title：Chinese medical journal

authors： Yu Q,Huang S,Ye L,Feng L,He F,Ye J,Gu C,Ge Q

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To explore the immune promotion mechanism of retinoic acid (RA). METHODS:Reverse Transcription-Polymerase chain reaction (RT-PCR) was used to detect the gene expression of insulin like growth factor I (IGF-I) and IGF receptors (IGF-IR and IGF-IIR) in vitro, and their regulation by RA in human cord blood lymp...

journal_title：Chinese medical journal

authors： Yang Y,Wang W,Su Y

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:To study whether human umbilical cord blood CD34+ cells transduced with human aldehyde dehydrogenase class-1 (ALDH-1) and multidrug resistance gene (MDR1) have increases resistance to 4-Hydroperoxycyclo-phosphamide (4-HC) and P-glycoprotein effluxed drugs. METHODS:A bicistronic retroviral vector G1Na-ALDH1-I...

journal_title：Chinese medical journal

authors： Wang J,Chen Z,Xia X,Lu D,Xue J,Ruan C

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinical value of sequential subtraction scintigraphy (SSS) with 99mTc red blood cell (RBC) for the early detection of gastrointestinal (GI) bleeding. METHODS:Ninety patients referred with clinical evidence of GI bleeding underwent 99mTc-RBC scintigraphy with digital gamma camera after labeli...

journal_title：Chinese medical journal

authors： Wu Y,Seto H

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To study whether liver cirrhosis associated with Helicobacter pylori (H. pylori) infection will induce increased serum ammonia and whether the peripheral serum ammonia reflects the level of portal vein serum ammonia. METHODS:Blood was taken from the portal vein and the cubital vein in cirrhotic patients with...

journal_title：Chinese medical journal

authors： Si J,Cao Q,Gao M,Fang L,Qian G,Wang Y

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:To characterize the mRNA expression of CXC chemokine IL-8, CC chemokine monocyte chemothractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES), and a newly defined DC chemokine DC-CK1 as well as the expression of IL-8 receptor, MCP-1 receptor and RANTES receptor i...

journal_title：Chinese medical journal

authors： Zhu K,Shen Q,Ulrich M,Zheng M

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:To study the clinicopathologic features and immunoprofile of angiomyofibroblastoma (AMF) with emphasis on differential diagnosis. METHODS:Seven vulvar, two vaginal and one perineal angiomyofibroblastomas were evaluated by light microscopy and immunohistochemistry. The immunohistochemical studies were perform...

journal_title：Chinese medical journal

authors： Wang J,Sheng W,Tu X,Shi D,Zhu X,Zhang R

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:To investigate the role of bax in a vincristine (VCR)-induced multidrug-resistant (MDR) human gastric cancer cell line, SGC7901/VCR, in which the Bax protein expression level was significantly lower compared with that in parent cells. METHODS:A bax eukaryotic expression vector was constructed and transfected...

journal_title：Chinese medical journal

authors： Zhao Y,Xiao B,Chen B,Qiao T,Fan D

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:To study mitogen-activated protein kinase (MAPKs) activation in fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA) under the stimulation of IL-1 beta, and to elucidate the role of protein tyrosine kinase (PTK) in the activation of MAPKs. METHODS:Primary cultures of RA FLS were used. Western blo...

journal_title：Chinese medical journal

authors： Lu H,Sun T,Yao L,Zhang Y

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:To assess the value of noninvasive three-dimensional computed tomographic angiography (3D-CTA) in preoperative detection of intracranial arteriovenous malformations (AVMs). METHODS:A prospective evaluation at a single institute over a 2-year period included 23 patients suspected of intracranial AVMs. All pat...

journal_title：Chinese medical journal

authors： Wu J,Chen X,Shi Y,Chen S

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:Polymorphism in vitamin D receptor (VDR) gene has been reported to play a major role in variations for genetic regulation of bone mass. Its role within various ethnic populations is not clear. The purpose of this study was to determine the frequencies of VDR genotypes in the Han and Uygur nationalities in Chi...

journal_title：Chinese medical journal

authors： Zhang H,Tao G,Wu Q,Liu J,Gao Y,Chen R,Leng X

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:To assess the therapeutic effects of long-term albendazole therapy in intraabdominal cystic echinococcosis. METHODS:Fifteen patients with a total of 45 cysts were treated with albendazole with dosage regimen of 20 mg.kg-1.d-1 for an average of 2.5 years. Repeated CT and ultrasound scannings (US) were perform...

journal_title：Chinese medical journal

authors： Liu Y,Wang X,Wu J

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:To characterize effects of the GP Ib alpha mutation (A156V) on its interaction with von Willebrand factor (vWf) under high fluid shear stress. METHODS:The residue A156 of GP Ib alpha was converted to a valine and the mutant expressed in CHO cells expressing wild-type GP Ib beta and GPIX. The transfected cell...

journal_title：Chinese medical journal

authors： Dong J,Li C,Schade AJ,Fredrickson BJ,Sun L,McIntire LV,López JA

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVES:To examine whether the expression of choline acetyltransferase (ChAT), a marker for cholinergic neurons, and growth-associated protein (GAP-43), a marker for synaptogenesis, occurs differently following compression vs. decompression of spinal cord, and whether the reactions have any relationship with the tim...

journal_title：Chinese medical journal

authors： Chen Q

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:To investigate the protective effect of dl-3-n-butylphthalide (NBP) as an anti-cerebral ischemic drug on brain damage 24 h after closed head injury in mice. METHODS:Closed head injury was induced by dropping a 50-g weight from a height of 18 cm on a metal impounder resting on the parietal bone in mice. RESU...

journal_title：Chinese medical journal

authors： Chong Z,Feng Y

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:To isolate and clone the tumor suppressor gene on chromosomal region 7q32 correlated with the carcinogenesis of human nasopharyngeal carcinoma (NPC). METHODS:The genotypes of polymorphic microsatellite markers on 7q32 in DNA from 24 biopsies of nasopharyngeal carcinoma and matched normal blood cells were ide...

journal_title：Chinese medical journal

authors： Jiang N,Zhan F,Tan G,Deng L,Zhou M,Cao L,Qiu Y,Xie Y,Li G

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:To study the ultrastructural damages of brain tissues dynamically after middle cerebral artery obstruction (MCAO). METHODS:A middle cerebral artery obstruction (MCAO) model was reproduced in renal vascular hypertensive rats (RHR). Brain tissues in different locations were collected for eight times in row, fr...

journal_title：Chinese medical journal

authors： Fang Y,Huang R,Su Z,Lin J,Li J

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:To investigate the use of the Gibbs-Sampler method in evaluating the relationship between clinic events and health risks in a meta-analysis of multiple clinical trials. METHODS:By using a generalized linear model with random-effects, Gibbs-Sampler technique was used in a meta-analysis of multiple clinical tr...

journal_title：Chinese medical journal

authors： Wang Y,Wang Y,Li L,Wang Z,Macus F,Salim Y

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:To assess the clinical significance of radionuclide techniques in evaluating dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (CAD-CM). METHODS:28 patients with DCM and 55 patients with CAD-CM were studied. All patients underwent 99mTc-MIBI myocardial perfusion SPECT and 18F-FDG myocardial metabolic ...

journal_title：Chinese medical journal

authors： Tian Y,Liu X,Shi R,Liu Y,Wu Q,Zhang X

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To clarify whether genetic variants of the renin-angiotensin system (RAS) contribute to the development of diabetic nephropathy (DN) in the Chinese. METHODS:Totally 173 Chinese subjects of Han nationality from Shanghai were classified into! control, DN (-) and DN (+) groups. The latter was subdivided accordi...

journal_title：Chinese medical journal

authors： Wu S,Xiang K,Zheng T,Sun D,Weng Q,Zhao H,Li J

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety and immunogenicity of lyophilized, live attenuated hepatitis A vaccine (H2 strain) in rhesus monkeys. METHODS:Nine adult rhesus monkeys were used as experimental animals. The rhesus monkeys without anti-HAV were divided randomly into the aqueous vaccination group (4 rhesus monkeys), th...

journal_title：Chinese medical journal

authors： Hu Y,Tan S,Shao C,Jin W,Ji Q,He J,Chen H,Yan J

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:To investigate the short- and long-term clinician and angiographic outcome of stenting or angioplasty for chronic total coronary artery occlusion. METHODS:A total of 95 patients with successful percutaneous transluminal coronary angioplasty (PTCA) for total occlusion coronary artery were identified out of 35...

journal_title：Chinese medical journal

authors： Dong S,Jeong M,Cho J,Kang J

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:To assess the effects of Dy-DTPA-BMA (sprodiamide) on ex-vivo MR imaging of reperfused acute myocardial infarction. METHODS:Eighteen dogs were subjected to 2-hour coronary artery occlusion followed by 24-hour reperfusion. Dysprosium-chelate (Dy-DTPA-BMA) was injected into 16 dogs. Twenty minutes before their...

journal_title：Chinese medical journal

authors： Zhao S,Revel D,Arteaga C,Canet E,Liu S,Hadour G,Forrat R,Oksendal A

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:To investigate all-trans retinoic acid (ATRA) and As2O3 which were found to be able to selectively induce differentiation and apoptosis in acute promyelocytic leukemia (APL) and recently became standard treatment for de novo or relapsed APL. The results of long-term follow up in 72 APL patients were presented...

journal_title：Chinese medical journal

authors： Hu J,Shen Z,Sun H,Wu W,Li X,Sun G,Wang Z

更新日期：2000-02-01 00:00:00